盐酸戊乙奎醚治疗中重度有机磷中毒

Penehyclidime hydrochloride in treatment for patients with moderate and severe organophosphorus poisoning

抢救149例中重度有机磷中毒患者，72例肌内注射盐酸戊乙奎醚和氯磷定（盐酸戊乙奎醚组），77例阿托品静脉注射＋氯磷定肌内注射（阿托品组）。盐酸戊乙奎醚组阿托品化时间、用药次数、症状消失时间、胆碱酯酶恢复时间、住院时间均优于阿托品组（P〈0．05）；盐酸戊乙奎醚组阿托品中毒率、阿托品依赖率、中毒反跳率以及不良反应明显低于阿托品组（P〈0．05）。

One hundred and forty-nine patients with moderate and severe organophosphorus poisoning were treated in Fangshan District Hospital, Beijing during July 2005 to July 2007, 77 cases of them with intravenous atropine and intramuscular pyraloxime methylehloride and 72 with intramuscular penehyclidime hydrochloride plus pyraloxime methylchloride. Time of atropinization, number of medication injection, time of symptom disappearance, recovery time of cholinesterase, length of hospital stay in those with penehyclidime hydroehloride plus pyraloxime methylchloride were all better than those with atropine and pyraloxime methylchloride （P 〈 0. 05 ） . Percentage of atropine poisoning, atropine dependence, organophosphorus poisoning rebound and adverse reaction in those with penehyclidime hydrochloride plus pyraloxime methylchloride were lower than those in those with atropine and pyraloxime methylchloride （P 〈 0.05）.