布鲁菌病9例附文献复习

Nine cases of brucellosis and literature review

目的分析布鲁菌病流行病学、临床特点、治疗和转归,以提高对布鲁菌病的认识。方法回顾性分析2003—2008年我院感染科收治的9例布鲁菌病,并作文献复习。结果9例患者均有明确的流行病学史,临床表现均有发热、多汗、乏力,其中5例患者除上述症状外分别伴有脑膜炎、关节痛、尿路感染、睾丸炎和游走性肌痛表现。血培养阳性5例,血清抗体阳性9例。9例患者经内科积极治疗后均治愈。结论布鲁菌病临床表现多样,对长期不明原因发热者应结合流行病学特点考虑布鲁菌病可能,血培养和血清抗体检测是有效的诊断手段。多西环素联合链霉素、庆大霉素或利福平是有效的治疗手段。

Objective To analyze and review the epidemiology, clinical features, treatment and prognosis of brucellosis. Methods This was a retrospective review of in-patients treated for brucellosis during 2003 and 2008 in our hospital and the associated literature. Results A total of 9 cases were included. All the patients had history of epidemic exposure. The common clinical presentations included fever, hyperhidrosis and weakness. Meningitis, arthralgia, urinary tract infection, orchitis or migratory myalgia was identified in one patient each. Five patients had positive blood culture. All 9 cases were positive for serum antibodies. All cases were cured after active medical management. Conclusions The clinical manifestation of brucellosis is various. Epidemiological feature combined with long-terra fever of unknown origin may suggest the possibility of brucellosis. Blood culture and serum antibody assay are effective diagnostic tools. Doxycycline combined with streptomycin, gentamiein, or rifampin is ef fective treatment.