先天性心脏病患儿血清氨基酸浓度的改变

Changes in Serum Levels of Total Amino Acids in Young Children with Congenital Heart Diseases

目的探讨早期手术治疗对改善先天性心脏病（先心病）患儿蛋白质营养不良的意义。方法用氨基酸自动分析仪测定７２例先心病患儿术前和术后的１６种血清游离氨基酸浓度，并以５１例健康儿童血清游离氨基酸浓度作对照。结果先心病患儿血清必需氨基酸总量降低，其中以支链氨基酸下降为主，对低年龄患儿的影响显著。经手术矫正先心病后１个月，血清氨基酸浓度均恢复到正常水平。结论先心病患儿存在蛋白质营养不良，低年龄儿患儿更严重。

Objective To study the implication of early surgical operation on the improvement of protein malnutrition in young children with congenital heart diseases. Methods Sixty six kinds of serum free amino acids were determined with an automatic analyzer for 72 cases with congenital heart diseases before and after surgical operation and 51 healthy children. Results Serum total amount of essential amino acids reduced in children with congenital heart diseases, mainly of branch chained amino acids, especially significant in young ones. Serum amino acids restored to normal level one month after surgical operation. Conclusion There existed protein malnutrition in children with congenital heart diseases, especially in young ones. Surgical operation for them in a suitable time will improve their protein nutritional status.