脑血管意外与血脂水平的研究

Studies on Stroke and Blood Lipid Level

目的阐明血脂与脑血管病的关系。方法检测了２０８例脑血管病患者７项血脂指标。甘油三酯、总胆固醇及高密度脂蛋白胆固醇用酶法测定，载脂蛋白ＡＩ、载脂蛋白Ｂ１００及脂蛋白（α）用免疫多点定标法测定，低密度脂蛋白胆固醇按公式计算。结果脑梗塞组甘油三酯、总胆固醇、低密度脂蛋白胆固醇、载脂蛋白Ｂ１００及脂蛋白（α）水平显著高于对照组，甘油三酯、载脂蛋白Ｂ１００水平也显著高于脑出血组；脑出血组与对照组血脂水平比较差异无显著。结论血脂代谢紊乱是脑梗塞的危险因素。

Objective To elucidate the relationship between blood lipid levels and cerebrovascular diseases. Methods Seven indicators for blood lipid were determined in 208 patients with cerebrovascular diseases. Triglyceride (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL C) were measured with enzyme methods, apolipoprotein A Ⅰ, apolipoprotein B 100 (Apo B 100 ) and lipoprotein (α) were measured with immune multifocal method, and low density lipoprotein cholesterol (LDL C) was calculated according to Friedewald formula. Results Levels of TG, TC, LDL C, Apo B 100 and Lp(α) in patients with cerebral infarction were significantly higher than those in the controls, and levels of TG and Apo B 100 in them were also significantly higher than those in the patients with cerebral hemorrhage. There was no significant difference in blood lipid levels between the patients with cerebral hemorrhage and the controls. Conclusion It suggests that disturbance of blood lipid metabolism is a risk factor for cerebral infarction.