食管癌组织中nm23-H_1蛋白表达及其临床意义

Expression of nm23 H 1 Protein and Its Clinical Significance in Esophageal Carcinomas

为探讨ｎｍ２３Ｈ１蛋白表达在食管癌中的临床意义，应用免疫组化ＳＰ法研究了６１例食管癌组织标本中ｎｍ２３Ｈ１蛋白表达与食管癌临床病理特征及预后的关系。ｎｍ２３Ｈ１蛋白阳性表达率为５４．１％（３３／６１），表达与性别、年龄、肿瘤部位、大小、病理类型及浸润程度无关。食管癌旁无淋巴结转移组ｎｍ２３Ｈ１阳性表达率为６１．５％（３２／５２），显著高于有转移组（１１．１％，１／９）。此外与术后肿瘤转移、复发有关，ｎｍ２３Ｈ１阳性表达组的术后生存时间明显长于ｎｍ２３Ｈ１阴性表达组（Ｐ＜０．０１）。结果表明：ｎｍ２３Ｈ１蛋白高表达对食管癌转移有一定的抑制作用，检测其表达有助于对食管癌生物学行为的了解和预后的判断。

To study the expression of nm23 H 1 protein and its clinical significance in esophageal carcinomas,the expression of nm23 H 1 protein was detected by SP immunohistochemical method.The positive rate of nm23 H 1 protein in esophageal carcinomas was 54.1%(33/61).The rate of nm23 H 1 protein positive expression was 61.5% in the carcinomas without lymph node metastasis.Its expression was not correlative with sex、age、tumor position、size、pathological type and infiltration( P >0.05),but associated with tumor metastasis( P <0.01)、recurrence and survival time of postoperation( P <0.05 and P <0.01).It is suggested that the high expression of nm23 H 1 protein might play an inhibiting regulation role in esophageal carcinoma metastasis and might have predictive value for prognosis of human esophageal carcinomas.