摘要
目的观察大蒜素联合阿昔洛韦对预防复发性生殖器疱疹(RGH)复发的疗效和血清IL-2、IFN-γ的影响。方法84例RGH患者随机分为大蒜素联合阿昔洛韦组(联合组)和单用阿昔洛韦治疗组(单用组)各42例,观察停药后1a内复发情况和每次复发时皮损、症状消失时间,并采用ELISIA检测治疗前后患者血清中IL-2、IFN-γ水平。结果联合组随访1a内的复发次数明显少于单用组(1.02±0.78vs2.94±0.92,P<0.01);联合组治疗后的血清IL-2、IFN-γ水平明显高于治疗前和单用组治疗后(P<0.01),而单用组治疗前后血清IL-2和IFN-γ水平均无明显变化(P>0.05)。结论大蒜素联合阿昔洛韦治疗RGH可减少复发,提高患者的细胞免疫。
Objective To observe the effect of combination of allicin and acyclovir on the relate prevention of recurrent genital herpes (RGH) and serum IL-2 and IFN-T levels. Methods Eighty-four RGH patients were randomly divided into allicin + acyclovir group and acyclovir group, each 42 cases. The relapse rate and recurrent symptoms were recorded within a year after the treatment. Serum levels of IL-2 and IFN-γ were determined by ELISA. Results The relapse rate in allicin + acyclovir group was significantly lower than that in acyclovir group [ ( 1.02 ±0.78) vs (2.94 ±0.92), P〈 0.01 ]. Serum levels of IL-2 and IFN-γ increased significantly after the treatment with allicin + acyclovir than before the treatment, and than after the treatment with acyclovir alone (P〈 0.05). There were no statistical differences between the pre- and post-treatment with acyclovir alone (P〉0.05). Conclusion Combined treatment with allicin + acyclovir can reduce the relapse rate and improve the cellular immunity in RGH patients.
出处
《广东医学院学报》
2009年第4期375-376,共2页
Journal of Guangdong Medical College