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新型有机阳离子转运体-2调控研究进展 被引量：3

Advances in the study of regulation of novel organic cation transporter-2
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摘要 新型有机阳离子转运体-2(OCTN2)是有机阳离子转运体家族成员,可转运肉毒碱及多种有机阳离子类药物,具有重要的生理学和药理学研究价值。大量研究表明,多种因素可通过不同的机制对转运体表达及功能产生一定的作用,从而可能对机体内环境的稳定和药物的处置产生影响。本文综述了OCTN2调控研究的最新进展。 Novel organic cation transporter-2（OCTN2）,a member of the organic cation transporter family,may transport carnitine and multiple organic cationic drugs.Thus OCTN2 possesses substantial roles in physiology and pharmacology.A number of researches have proven that many factors can regulate the expression and/or function of OCTN2 via different pathways,and then may affect the homeostasis and disposition of drugs.This paper reviews recent progresses in this field.
作者 王芙蓉 郭瑞臣
机构地区 山东大学齐鲁医院 山东中医药大学
出处 《药学学报》 CAS CSCD 北大核心 2009年第10期1061-1065,共5页 Acta Pharmaceutica Sinica
关键词 新型有机阳离子转运体-2 PDZ结构域 多态性 PPARΑ novel organic cation transporter-2 PDZ domain polymorphism PPARα
分类号 R963 [医药卫生—微生物与生化药学]
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参考文献43

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同被引文献28

  • 1刘涛,刘克辛.药物转运体的变化对肝脏疾病的影响[J].中华临床医师杂志（电子版）,2011,5(10):2982-2985. 被引量：4
  • 2郭晓强.CFTR型氯离子通道研究进展[J].生命科学,2007,19(2):189-193. 被引量：6
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  • 6Matsuzaki T, Morisaki T, Sugimoto W, et al. Altered pharmacoki-netics of cationic drugs caused by down - regulation of renal rat or-ganic cation transporter 2 ( Slc22a2) and rat multidrug and toxin ex-trusion 1 ( Slc47al ) in ischemia/reperfusion - induced acute kidneyinjury[ J]. Drug Metab Disposit :Biol Fate Chem,2008 ;36 ;649 -654.
  • 7Dantzler WH. The use of mammalian cortical kidney slices for thestudy of tubule secretion: a pioneering step toward understanding or-ganic anion transport[ J]. Am J Physiol Renal Physiol,2006 ;290 : 1-3.
  • 8Taft DR. The isolated perfused rat kidney model a useful tool fordrug discovery and development [ J]. Cun Drug Discov Technol,2004;1:97-111.
  • 9Lepsy CS,Guttendorf RJ,Kugler AR,et al. Effects of organic ani-on ,organic cation,and dipeptide transport inhibitors on cefdinir inthe isolated perfused rat kidney [ J ]. Antimicrob Agents Chemother,2003 ;47 :689 -696.
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药学学报
2009年 第10期

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