金刚纂萜类成分研究

Terpenoids from Euphorbia antiquorum L.

利用正相和反相硅胶柱色谱法等手段,从金刚纂乙酸乙酯提取物中分离得到7个萜类化合物。化合物经波谱分析鉴定为antiquorine A(1)、antiquorine B(2)、ent-13S-hydroxy-16-atisene-3,14-dione(3)、taraxerol(4)、3β-hydroxy-25,26,27-trisnorc ycloart-24-oic acid(5)、9β,19-cyclolanostan-3β-ol(6)和Ψ-taraxastane-3,20-diol(7)。化合物1～3为二萜,其结构类型分别属于松香烷型、对映贝壳烷型和阿替烷型,其中化合物1和2为新化合物。化合物4～7为三萜,其中化合物5为降解的环阿廷烷型三萜,为新的天然产物,化合物7为首次从该植物中分离得到。本研究表明了该植物中化学结构的多样性。

To study the chemical constituents of Euphorbia antiquorum L.,the constituents were isolated with normal-phase and reverse-phase silica gel column chromatography and their structures were elucidated on the basis of spectroscopic data.Seven terpenoids were obtained from EtOAc extract of E.antiquoru L.They were identified as antiquorine A（1）,antiquorine B（2）,ent-13S-hydroxy-16-atisene-3,14-dione（3）,taraxerol（4）,3β-hydroxy-25,26,27-trisnorcycloart-24-oic acid（5）,9β,19-cyclolanostan-3β-ol（6） and Ψ-taraxastane-3,20-diol（7） by spectral analysis.Compounds 1-3 are diterpenoids,which belonged to abietane,ent-kaurane and atisane respectively.Among them,compounds 1 and 2 are new compounds.Compounds 4-7 are triterpenoids,and compound 5 is a degraded cycloartane triterpenoid which is a new natural product.Compound 7 was isolated from this plant for the first time.It demonstrated that the chemical structures of constituents in this plant were diverse.