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nm_(23)-H_1,PCNA,CD_(15)表达与肺癌区域性淋巴结转移的关系 被引量:1

The relation between the expression of nm_(23)-H_1,PCNA, CD_(15)and metastasis of lung Carcinoma
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摘要 应用免疫组化S-P法,研究47例原发性肺癌手术标本中nm23-H1,PCNA,CD15的表达及其与区域性淋巴结转移的关系。结果显示:在原发性肺癌中nm23-H1,PC-NA,CD15的阳性表达分别为51.06%,65.96%,51.06%。其中nm23-H1在鳞癌中阳性表达43.3%(13/30),腺癌64.71%(11/17),腺瘤表达较鳞癌高。在鳞癌中无肺门及纵隔淋巴结转移者阳性62.50%(10/16),有转移者阳性21.41%(3/14)(P<0.01),显示nm23-H1表达与鳞癌的肺门及纵隔淋巴结转移呈负相关。在PCNA表达中,有区域淋巴结转移的阳性表达为82.6%(19/23),无淋巴结转移为54.16(13/24)(P<0.01),低分化癌阳性表达88.8%(8/9),明显高于高分化癌43.75%(7/16),(P<0.01)。在CD15表达中,有淋巴结转移组中阳性表达为78.26%(18/23),无区域性淋巴结转移组中阳性表达25%(P<0.01)。而nm23-H1,PCNA,CD15表达之间无显著相关性。本研究提示nm23-H1,PCNA,CD15的表达对肺癌预后评估有重要意义。 To study of the relation between metastasis and the expression of nm23-H1,PCNA,CD15 in human lung carcinoma. The expression of nm23-H1,PCNA, CD15in 47 cases human lung carcinoma was studied with SPimmunohistochemical technique. In human lung carcinoma expressions of nm23-H1,PCNA, CD15were 51. 6 %, 65. 96 %and 51. 06%. The positive rate of nm23-H1 in squamous cell carcinoma was 43. 33%, adenocarcinoma 64.7%. The positive rate in the adenocarcinoma was higher than the squamous cell carcinoma. The positive rate in squamors cell carcinoma without metastasis of hilar or mediastinal lymph node was 62. 5 % (10/16), compared with these with metastasis of lymph node was 21. 4 % (3/14), (P < 0. 001 ). The level of nm23-H1 expression was inversely correlated with lymph node metastasis in squamous cell carcinoma. The positivity of PCNA in the cases with lymph node metastasis was 82. 6% (19/23) and those without metastasis was 54. 16% (P<0. 001). The rate of positivity of PCNA in the poorly differentiated carcinoma was 88. 88% (8/9) and cases of with the well differentiatde carcinoma was 43. 75% (7/16) (P<0. 001 ). The rate of positivity of CD15in cases of with lymph node metastasis was 78. 26% (18/23) and in those without metastasis was 25%(P<0. 001). The expression of nm23-H1,PCNA and CD15may be helpful to evaluate the prognosis of lung carcinoma.
机构地区 青岛市肿瘤医院
出处 《肿瘤防治研究》 CAS CSCD 北大核心 1998年第6期448-450,共3页 Cancer Research on Prevention and Treatment
关键词 肺肿瘤 基因表达 淋巴结转移 PCNA CD15 NM23 lung neoplasms gene expression immunohistochemstry
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  • 1Zhu D,PNAS,1991年,88卷,21期,9568页
  • 2Chan B M,Science,1991年,251卷,5001期,1600页

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