nm_(23)-H_1,PCNA,CD_(15)表达与肺癌区域性淋巴结转移的关系

The relation between the expression of nm_(23)-H_1,PCNA, CD_(15)and metastasis of lung Carcinoma

应用免疫组化S－P法，研究47例原发性肺癌手术标本中nm23－H1，PCNA，CD15的表达及其与区域性淋巴结转移的关系。结果显示：在原发性肺癌中nm23－H1，PC－NA，CD15的阳性表达分别为51．06％，65．96％，51．06％。其中nm23－H1在鳞癌中阳性表达43．3％（13／30），腺癌64．71％（11／17），腺瘤表达较鳞癌高。在鳞癌中无肺门及纵隔淋巴结转移者阳性62．50％（10／16），有转移者阳性21．41％（3／14）（P＜0．01），显示nm23－H1表达与鳞癌的肺门及纵隔淋巴结转移呈负相关。在PCNA表达中，有区域淋巴结转移的阳性表达为82．6％（19／23），无淋巴结转移为54．16（13／24）（P＜0．01），低分化癌阳性表达88．8％（8／9），明显高于高分化癌43．75％（7／16），（P＜0．01）。在CD15表达中，有淋巴结转移组中阳性表达为78．26％（18／23），无区域性淋巴结转移组中阳性表达25％（P＜0．01）。而nm23-H1，PCNA，CD15表达之间无显著相关性。本研究提示nm23－H1，PCNA，CD15的表达对肺癌预后评估有重要意义。

To study of the relation between metastasis and the expression of nm23-H1,PCNA,CD15 in human lung carcinoma. The expression of nm23-H1,PCNA, CD15in 47 cases human lung carcinoma was studied with SPimmunohistochemical technique. In human lung carcinoma expressions of nm23-H1,PCNA, CD15were 51. 6 %, 65. 96 %and 51. 06%. The positive rate of nm23-H1 in squamous cell carcinoma was 43. 33%, adenocarcinoma 64.7%. The positive rate in the adenocarcinoma was higher than the squamous cell carcinoma. The positive rate in squamors cell carcinoma without metastasis of hilar or mediastinal lymph node was 62. 5 % (10/16), compared with these with metastasis of lymph node was 21. 4 % (3/14), (P < 0. 001 ). The level of nm23-H1 expression was inversely correlated with lymph node metastasis in squamous cell carcinoma. The positivity of PCNA in the cases with lymph node metastasis was 82. 6% (19/23) and those without metastasis was 54. 16% (P<0. 001). The rate of positivity of PCNA in the poorly differentiated carcinoma was 88. 88% (8/9) and cases of with the well differentiatde carcinoma was 43. 75% (7/16) (P<0. 001 ). The rate of positivity of CD15in cases of with lymph node metastasis was 78. 26% (18/23) and in those without metastasis was 25%(P<0. 001). The expression of nm23-H1,PCNA and CD15may be helpful to evaluate the prognosis of lung carcinoma.