重新编程与白血病干／祖细胞的起源与演化

Reprogramming in Origin and Development of Leukemia Stem/Progenitor Cells——Editorial

由体细胞建立诱导性多潜能干细胞系(iPS)的成功证明重新编程在干细胞生成中的重要作用,引发对白血病干/祖细胞起源的思考。白血病干/祖细胞的起源和演化是白血病发生发展的核心。白血病有两类不同类型,真正的白血病(bona fide leukemia)和非真正的白血病(non-bona fide leukemia),不同类型的白血病有不同起源的白血病干/祖细胞,近年来的研究进展表明它们受起源细胞的重新编程状态影响。

The success of yielding induced pluripotent stem （ iPS ） cells from human somatic cells demonstrates the important role of reprogramming in the formation of stem/progenitor cells and initiates the exploration of the origin of leukemia stem cells. In our previous work, we have found two types of leukemia, bona fide leukemia and non-bona fide leukemia. Different leukemias originate from different leukemia stem/progenitor cells which are critical to the genesis and evolution of leukemia. Bona fide leukemia and non-bona fide leukemia originate from leukemia stem cells and pro- genitor cells, respectively. Recent research suggests that different types of leukemia are influenced by the reprogramming state of their origin cells.