摘要
目的:观察仙鹤草(agrimoniapilosaledeb,APL)对人癌细胞裸鼠移植瘤的影响.方法:采用MTT和人癌细胞裸鼠荷瘤模型进行实验.结果:10mg/LAPL对MgC803,SPC-A-1和Hela人癌细胞均有显著抑制(P<0.01);100及200mg/kgAPL对Mgc803。裸鼠移植瘤瘤重抑制率分别为34.6%和48.5%(P<0.05和P<0.01);SPC-A-1为39.6%和49.3%(P<0.05);Hela为20.6%和42.6%(P<0.05).结论:APL对Mgc803,SPC-A司和Hela人癌细胞及其裸鼠移植瘤具有明显抑制作用.
Aim: To explore the effect of APL on nude micebearing human cancerous xenograft. Methods: MTT andnude mice transplantation tumor models were used in ourexperiments. Results: 10 mg/L APL inhibited the grouwthof Mgc803,SPC-A-1 and Hela human caricer cells obviously.The inhibition rates of 100 mg/kg and 200 mg/kg APL toMgc803 nude mice transplantation tumor were 34. 6%,48. 5% (P<0. 05 or 0. 01 ) respectively, to SPC-A-1 were39. 6% and 49. 13% (P<0. 05), to Hela were 20. 6% and42. 6% (P<0. 05). Conclusion: APL has notable inhibitionto nude mice bearing human Mgc803 or SPC-A-1 and Helacancerous xenograft.
出处
《第四军医大学学报》
1998年第6期702-704,共3页
Journal of the Fourth Military Medical University
关键词
仙鹤草
中药
癌细胞
移植瘤
Agrimonia piolosa Ledeb Chinese herbs cancer cells nude mice transplantation tumor