胶质瘤血管生成拟态的初步研究

Initial Study on Vasculogenic Mimicry in Glioma

目的探讨在胶质瘤中是否存在血管生成拟态现象并进一步阐述血管生成拟态的结构特点及其存在的临床意义。方法收集临床及随访资料完整的胶质瘤石蜡标本,其中高度恶性和低度恶性各40例,进行FⅧRag、GFAP免疫组织化学染色和PAS组织化学染色及双重染色,然后进行形态学观察及统计学分析。结果胶质瘤中高度恶性组FⅧRag和PAS阳性计数之间的差别具有显著性差异(P<0.01),而低度恶性组FⅧRag和PAS阳性计数之间的差别没有显著性差异(P>0.05);在双重染色的组织切片上观察到典型的血管生成拟态图像及马赛克血管。结论在胶质瘤中存在血管生成拟态现象,且恶性度越高形成拟态血管能力越强。

Objective To investigate whether vasculogenic mimicry （VM） exists in glioma,and to explain the construction features and clinical significance of VM. Methods 40 cases of highly invasive glioma and 40 cases of poorly invasive glioma with complete clinical and prognostic data were collected and reprocessed as tissue sections for further investigation. The tissue sections were then stained with FⅧRag, GFAP, PAS and dual stained;and the positivity rates were compared and observed. Results There was a significant difference between FⅧRag and PAS staining in highly invasive glioma （P 〈 0.01 ） ;the difference was not statistically significant in poorly invasive glioma （P 〉 0.05 ） ; the typical patterns of VM and mosaic were observed. Conclusion Vasculogenic mimicry exists in glioma, and the higher invasive glioma exists more VM.