氯化镉染毒对红鲫脂质过氧化作用的影响

Effects of Cadmium Chloride on Lipid Peroxidation in Carassius Auratus Red Variety

目的探讨镉染毒对纯种红鲫脂质过氧化作用的影响。方法将28尾两年龄纯种红鲫随机分为空白对照组和高(1.6mg/L)、中(0.8mg/L)、低(0.2mg/L)剂量镉染毒组,每组7尾,染毒30d。测定红鲫鳃及肝组织中总超氧化物歧化酶(T-SOD)活力、肝组织中丙二醛(MDA)含量及总抗氧化能力(T-AOC)。结果随着镉染毒浓度的升高,红鲫鳃、肝组织中的T-SOD活力均呈先升高后下降的趋势,红鲫肝组织中MDA含量呈上升趋势。红鲫肝组织中T-AOC呈先上升后下降的趋势。相同剂量镉染毒组红鲫鳃组织中的T-SOD活力均远低于肝组织,差异有统计学意义(P<0.01)。结论镉染毒可引起红鲫脂质过氧化损伤。

Objective To explore the effects of cadmium chloride on lipid peroxidation in Carassius A uratus red variety. Methods Twenty-eight Carassius Auratus red variety were randomly divided into control group and high （1.6 mg/L）,moderate （0.8 mg/L）,low （0.2 mg/L） dose cadmium exposure groups. The exposed groups were treated with cadmium chloride for 30 consecutive days. The total superoxide dismutase （T-SOD） activities in gill and liver tissues and the levels of malondialdehyde （MDA）, total antioxidant capacity （T-AOC） in liver tissues of Carassius A uratus red variety were detected. Results As cadmium exposure increasing,the activities of T-SOD in the liver and gill tissue of Carassius Auratus red variety increased at first, then getting down. As cadmium exposure increasing, the levels of T-AOC in liver tissue were all increased at first, and then getting down.At the same dose group, the activity of T-SOD in gill was significantly lower than that in the liver tissue. Conclusion Cadmium can cause lipid peroxidation damage in Carassius A uratus red variety.