周剂量多西紫杉醇联合小剂量顺铂、5-氟脲嘧啶持续静脉滴注治疗晚期胃癌的疗效观察

Observation of Weekly Dose of Docetaxel Combined with Small Doses of Cisplatin,5-Fluorouracil Continuous Intravenous Infusion Treatment of Advanced Gastric Cancer

目的评价周剂量多西紫杉醇联合小剂量顺铂、5-氟脲嘧啶(5-Fu)持续静脉滴注治疗晚期胃癌的临床疗效和毒副反应。方法48例晚期胃癌随机分为两组,试验组:多西紫杉醇35 mg/(m2.d)静滴,d1,8,15;顺铂6 mg/(m2.d),d1～5,d8～12;5-Fu 250 mg/(m2.d)微量输液泵维持持续静滴,d1～14,3周为1周期。对照组:顺铂75 mg/(m2.d),d1静滴;5-Fu 1 000 mg/(m2.d),d1～5,3周为1周期。治疗3～4个周期后评价疗效和毒副反应。结果试验组总有效率为45.8%;对照组总有效率为37.5%。两组有效率比较差异无统计学意义(P>0.05)。试验组较对照组白细胞下降(79.2%vs 45.8%);试验组腹泻(41.6%vs 20.8%)较对照组明显升高(P<0.05);试验组恶心、呕吐的发生率(33.3%vs 12.5%)低于对照组,差异均有统计学意义(P<0.05)。结论多西紫杉醇联合小剂量顺铂、5-Fu持续静脉滴注治疗晚期胃癌具有较好的疗效,毒副反应可耐受,是晚期胃癌化疗的有效方案。

Objective To evaluate the clinical efficacy and toxicity of weekly dose docetaxel combined with small doses of cisplatin,5-fluorouracil（5-Fu） continuous infusion for treatment of advanced gastric cancer.Methods 48 cases with advanced gastric cancer were randomly divided into two groups,the test group（A group）： docetaxel 35 mg/（m^2·d）,d1,8,15,cisplatin 6 mg/（m^2·d）,d1-5,d8-12;5-Fu 250 mg/（m^2·d） micro-infusion pump to maintain the continuous infusion,d1-14,three weeks for one cycle and the control group（B group）： cisplatin 75 mg/（m^2·d）,d1,5-Fu 1 000 mg/（m^2·d）,d1-5,three weeks for one cycle.3-4 months after the treatment cycle evaluation of the efficacy and adverse reactions.Results The total effective rate of the test group was 45.8%,the total effective rate of the control group was 37.5%.Difference between the two groups had no obvious statistical significance（P〉0.05）.The two groups had similar toxicity.In the hematological toxicity,the test group of patients with increased incidence of leukopenia（79.2% vs 45.8%）.Non-hematological toxicity,there was higher incidence of diarrhea（41.6% vs 20.8%） in the test group（P〈0.05）.In the control group,nausea and vomiting（33.3% vs 12.5%） had high incidence（P〈0.05）.Conclusion Docetaxel combined with small doses of cisplatin,5-Fu continuous infusion for treatment of advanced gastric cancer has better efficacy,adverse reactions can be tolerated.This kind of chemotherapy is effective options for advanced gastric cancer.