摘要
目的观察卡培他滨一线治疗老年进展转移期胃癌患者的疗效和安全性。方法口服卡培他滨片1 250 mg/m2,Bid,d1～14,q3w。每例至少治疗2个周期,2个周期后评价疗效。结果60例中,完全缓解(CR)6例(10.0%),部分缓解(PR)24例(40.0%),病灶稳定(SD)22例(36.7%),疾病进展(PD)8例(13.3%)。客观有效率(CR+PR)为50.0%(95%CI:28%～67.5%),临床控制率(CR+PR+SD)为86.7%(95%CI:58.1%～84.2%)。毒副反应主要为手足综合征、外周神经毒性、恶心呕吐、贫血等。结论卡培他滨一线治疗老年进展转移期胃癌疗效确切,毒副反应较少,患者耐受性好。
Objective Observation the curative effect and the security of capecitabine treatment of old age progress gastric carcinoma.Methods The oral administration of capecitabine 1 250 mg/m2,Bid,d1-14,q3w.Each example patient was treated at least for 2 cycles,after 2 cyclical chemotherapy,we appraised the curative effect.Results In 60 examples patients,CR 6 examples（10.0%）,PR 24 examples（40.0%）,SD 22 examples（36.7%）,PD 8 examples（13.3%）.The objective effective rate（CR＋PR） was 50.0%（95%CI： 28%-67.5%）,the clinical control rate（CR＋PR＋SD） is 86.7%（95%CI： 58.1%-84.2%）.Side effects mainly were hand and foot syndrome,circumference nerve toxicity,nausea and vomiting,anemia etc.Conclusion Capecitabine treatment of old age progress gastric carcinoma has obvious curative effect,untoward effect is few,patient tolerance is fine.
出处
《肿瘤基础与临床》
2009年第4期320-322,共3页
journal of basic and clinical oncology
关键词
胃癌
化疗
卡培他滨
gastric carcinoma
chemotherapy
capecitabine
