单药周剂量多西紫杉醇治疗老年晚期恶性肿瘤的临床观察

Weekly and Three-Weeks' Docetaxel Single-Treatment in Advanced Cancer of Elderly Patients

目的观察周剂量多西紫杉醇单药治疗老年晚期恶性肿瘤的疗效、毒副反应、临床受益反应。方法多西他赛25 mg/m2静滴,d1,8,15,28 d为1周期,完成2周期后评价疗效。至少治疗2个周期。结果68例均可评价疗效,总有效率为32.3%,其中非小细胞肺癌23例,有效率26.1%,胃癌14例,有效率28.5%,乳腺癌11例,有效率45.5%,前列腺癌12例,有效率41.7%,鼻咽癌8例,有效率25.0%,中位生存期为6.8个月,1年生存率及2年生存率分别为36.7%和22.0%。疾病相关症状显著改善,体力状态改善率60.3%,主要毒副反应为脱发及骨髓抑制。无治疗相关性死亡。结论周剂量多西紫杉醇单药治疗老年晚期恶性肿瘤有效率较高,毒副反应轻,耐受性好,并可以改善疾病相关症状,值得临床推广。

Objective To evaluate the efficacy and toxicity of a single trentment of weekly and three-weeks＇ docetaxel for elderly patients with advanced cancer and the clinical benefitial response.Methods Docetaxel 25 mg/m2 iv d1,8,15,each cycle lasted for 28 days,at least for 2 cycles.Results Sixty-eight patients were evaluated with 32.2%,twenty-three patients of NSCLC were evaluated with 26.1%,fourteen patients of gastric cancer were evaluated with 28.5%,eleven patients of breast cancer were evaluated with 45.5%,twelve patients of prostate cancer were evaluated with 41.7%,eight patients of nasal pharyngal cancer were evaluated with 25.0%.Median survival time was 6.8 months,the survival rate of 1 year and 2 years was 36.7% and 22.0%,the curative effect including easement of pain,obviously improvement of general state.Conclusion Better quality of existence and three weeks＇ docetaxel regimen may obtain high remission rate and low toxicity and better tolerated alternative and represents an option for the treatment of the elderly patients with advanced cancer.