金属硫蛋白对大鼠体内铅促排作用的研究

Study on the Effect of Metallothionein on Advancing Excretion of Lead in Rats

为了观察金属硫蛋白（ＭＴ）对铅的解毒作用，选用ＳＤ大鼠５０只，随机分为５组，每组１０只。其中一组为阳性对照，其余４组饮用含５％醋酸的铅水。同时每天以不同浓度的ＭＴ饮品灌胃（０，１．０，５．０，１０．０ｍＬ），连续观察５０天。结果表明饮用一定浓度的ＭＴ饮品的铅中毒大鼠血清ＳＨ值较未中毒时差异无显著性。服ＭＴ饮品组铅排泄量高于未服ＭＴ饮品组，而脑、肝、肾、股骨铅含量低于未服ＭＴ饮品组，说明ＭＴ饮品可促进体内铅的排泄，降低体内铅的蓄积。

To observe the effect of metallothionein (MT) on detoxification of lead,50 SD rats were divided into five groups (10 rats per group),one was positive control group,the other four were exposed to 5% solution of lead acetate by drinking and simultaneouly perfused perorally with different concentrations solution (0,1 0,5 0,10 0mL) of MT continuoutsly for 50 days The results indicated that the SH (mercapto) figures of serum in the Pb poisoning rats taking a certain concentration solution of MT were not significantly different from those in themself before Pb exposure,and in the same group the lead contents in excreta were higher,and the lead contents in brain,liver,kindey and femur were lower than those rats without taking MT solution It indicated that MT could advance the excretion of lead and decline the lead accumulation level in tissue and organ of rats