GC法测定胃舒胶囊中环氧乙烷残留量

Determination of the Residual Ethylene Oxide in Weishu Capsules by GC

目的建立气相色谱法测定胃舒胶囊中环氧乙烷残留量的方法。方法选择了宽口径毛细管柱DB-5,分流进样,在柱温为50℃时,气化室温度为200℃及检测器温度为200℃,氮气流速为2.2mL·min-1进行分离。结果环氧乙烷的线性范围0.3～12μg·mL-1(r=0.9997);平均回收率为93.60%(r=0.9999),检出限为0.1μg.g-1。结论本法简便快捷,结果准确可靠,可作为该成分的质量控制方法。

Objective To establish a GC method for the determination of ethylene oxide in WeiShu Capsules.Methods To choose width Capillary pillar DB-5,injection of splitness.The temperature was 50℃.The temperature of gasification room and detection room were all 200℃.The flow rate of N2 was 2.2mL·min-1.Results The calibration curve of ethylene oxide was linear within the range of 0.3～12μg·mL-1,r=0.9997.The average recovery rate was 93.60%（r=0.9999）.The detection limit was 0.1μg·g-1.Conclusions This method is simple and quick, and the result of determination is accurate and reliable.This method is suitable for quality control of ethylene oxide.