GC法测定利鲁唑含量

Determination of Riluzole by GC

目的建立GC法测定利鲁唑原料的含量的方法。方法采用气相色谱内标法。色谱柱为DB-1弹性毛细管柱,FID检测器;汽化室温度为260℃,检测器温度为260℃;柱温为230℃,载气为高纯氮气,流速为5.0mL·min-1,尾吹30mL·min-1,分流比5∶1,以咖啡因为内标物。结果利鲁唑在10～110μg.mL-1(r=0.9998)范围内呈良好线性关系,平均回收率为100.1%(RSD=0.36%)。结论本方法简便,快速,准确,可靠,可用于利鲁唑的含量测定。

Objective GC method for determination of riluzole was established.Methods The internal standard GC method was applied.The chromatographic system was consisted of DB-1 capillary column and FID as detector.The injector temperature was 260℃.Tthe detector temperature was 260℃.Oven temperature was 230℃.The flow rate of N2 was 5.0mL·min-1.Makeup flow was 30mL·min-1.Split ratio was 5∶1.Caffeine was used as internal standard.Results A good linearity of riluzole was obtained between 10～110μg·mL-1（r=0.9998）. The average recovery was 100.1% （RSD=0.36%）. Conclusions The method is simple, rapid and accurate, and can be used in quality control of riluzole.