序贯疗法与三联疗法根除幽门螺杆菌感染的成本-效果分析

Cost-effectiveness Analysis of Sequential Therapy vs.Triple Therapies for Helicobacter Pylori Infection

目的:评价不同治疗方案根除幽门螺杆菌(Hp)感染的效果及成本。方法:157例Hp感染的患者随机分为A、B、C组,A组53例前5天给予奥美拉唑+阿莫西林+替硝唑,后5天给予奥美拉唑+左氧氟沙星+克拉霉素;B组52例给予奥美拉唑+阿莫西林+替硝唑10天;C组52例给予奥美拉唑+左氧氟沙星+克拉霉素10天,进行成本-效果分析。结果:A、B、C组根除率分别为94%、74%、80%。成本-效果比分别为1 429.89、1 706.76、1 781.25。结论:A组方案为较佳方案。

OBJECTIVE： To evaluate the cost - effectiveness of different therapeutic schemes in the treatment of helicobacter pylori （Hp） infection. METHODS： A total of 157 Hp infection cases were randomly assigned to 3 groups： Group A （n = 53 ） received Omeprazole, Amoxicillin and Timidazole in the first 5 days followed by administration of Omeprazole, Levofloxacin and Clarithromycin for 5 days; Group B （n = 52） received Omeprazole, Amoxicillin and Timidazole for 10 days, while Group C （n -52） received Omeprazole, Levofloxacin and Clarithromycin for 10 days. Then the cost - effectiveness analyses of the 3 groups were conducted. RESULTS： The HP clearance rates in Group A, B and C were 94 %, 74 %, and 80 %, respectively, and the cost - effectiveness ratios of the three groups were 1 429.89, 1 706.76 and 1 781.25, respectively. CONCLUSION： Group A is preferable for HP infection.