摘要
目的:分析紫杉烷类注射剂过敏反应相关因素,为临床安全用药提供参考。方法:收集我院临床上报的31例紫杉烷类注射剂ADR病例报告,按患者一般情况、给药途径、用法用量、合并用药、过敏反应发生时间、临床表现、涉及的器官或系统、严重程度及转归进行统计分析。结果:31例紫杉烷类注射剂过敏反应多数发生于给药后15分钟以内,女性多于男性,既往有过敏史的患者用药后过敏反应发生率较高,严重过敏反应发生率为51.61%,预防用药和减慢滴注速度可减轻过敏反应程度。结论:临床应用紫杉烷类药物应加强用药监测和重视不良反应上报工作。
OBJECTIVE : To analyze the relevant factors of the anaphylaxis induced by taxanes injections for reference of clinical safe medication. METHODS: The ADR case reports of 31 cases collected in our hospital were analyzed statistically in respect of patients' general state, routes of administration, administration and dosage, drug combination, the onset time and clinical manifestation of the anaphylaxis, ADR - involved organs or systems, ADR severity and the clinical outcome. RESULTS: Of the total 31 anaphylaxis induced by taxanes injections, the majority occurred within 15 min after drug using, and which were more often seen in females than in males. Patients with allergic history had the high incidence rate of anaphylaxis. Serious anaphylaxis cases represented 51.61%. The severity of the anaphylaxis was lessened by preventive medication and slowing down of the dripping speed. CONCLUSIONS: It is necessary to strengthen monitoring and reporting of the ADRs induced bv taxanes injections.
出处
《中国医院用药评价与分析》
2009年第10期777-779,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
紫杉烷
过敏反应
临床观察
Taxanes
Anaphylaxis
Clinical observation