α-干扰素治疗重症轮状病毒肠炎72例疗效观察

Observation of Interferon-Treated the Serve Rotanvi rus Diarrhea in 72 Cases

目的观察α-干扰素治疗重症轮状病毒肠炎的临床效果。方法将142例重症轮状病毒肠炎,按照随机方法分为两组。对照组：应用病毒唑,10-15 mg/（kg.d）^-1,1次/d,静脉滴注,连用5 d;治疗组：应用α-干扰素2.0万U/（kg.d）^-1,1次/d,肌注,连用3 d。其他治疗两组相同。结果治疗组72例,12 h内治疗者26例,总有效26例,占100%。其中,显效24例,占92.3%;12-24 h治疗者24例,显效17例,占70.8%;24-48 h治疗者22例,显效9例,占40.9%。各组间均具有显著性差异（P〈0.05）。对照组70例中,12 h内治疗者23例,12-24 h治疗者28例,24-48 h治疗者19例,均无效,无效率均为100%。结论α-干扰素治疗重症轮状病毒肠炎具有极显著效果,而且用药越早效果越显著。病毒唑治疗该病无效。

Objective To observe the effect of Interferontreated with the serve mtanvirus diarrhea. Methods There were 142 cases suffering from serve mtanvirus diarrhea to divide into 2 groups, according to Random. Control group were treated with Ribavirin, 10- 15 mg/（kg·d）^-1, iv drip qd × 5. Interferon group were treated with Interferon, 20 000 U/ （kg· d）^-1, im qd3. Other treatment of 2 groups were identical. Results There were 72 cases in Interferon group. Beginning treatment within illness after 12 hours were 26 cases, effect were 26 cases （ 100% ）, marked effect were 24 cases （92.3%）; 12- 24 hours were 24 cases, marked effect were 17 cases （70.8%）; 24- 48 hours were 22 cases, effect were 22 cases （100%）, marked effect were 9 cases （40.9%）. From each other groups were statistically marked difference （ P 〈 0.05）, to marked effect to respond to Interferon. There were 70 cases in control group, Beginning treatment wi thin illness after 12 hours were 23 cases, 12 - 24 hours were 28 cases, 24 - 48 hours were 19 cases. The all cases were fall-to respond to Ribavirin. Conclusion Interferon in treating serve rotanvirus diarrhea has significant function, and if the treatment were earlier, the effect were better.