输液瓶的吸附作用对胰岛素输注过程中浓度变化的影响

Effects of Adsorption of Infusion Bottle on the Insulin Injection Concentration Changes in Clinical Transfusion

为了解胰岛素注射液在输液过程中的浓度变化情况,指导临床合理操作,模拟了临床胰岛素配液以及输注操作过程,实验分为玻璃瓶组和塑料瓶组,各组又按操作的不同分为输液组和吸附组.采用紫外分光光度法测定胰岛素浓度.输液组流速为50滴/min,每输注50 mL液体取样测定胰岛素浓度.吸附组按溶媒不同分为氯化钠组、50 g/L葡萄糖组和100 g/L葡萄糖组,每隔10 min轻轻振摇1次,并取液测定浓度.结果表明,不同材质和装有不同溶媒的输液瓶对胰岛素的吸附趋势类似,但塑料瓶对胰岛素的吸附量大于玻璃瓶,装有氯化钠的输液瓶大于葡萄糖输液瓶,100 g/L葡萄糖输液瓶大于50 g/L葡萄糖输液瓶.因此,在胰岛素输液过程中,应考虑到输液瓶对胰岛素的吸附导致的药量损失.

In order to understand the concentration changes of insulin injection in clinical transtusion and guide correct clinical operation,the infusion bottle＇s adsorption of the insulin injection was observed and studied.In the experiment,the same processes of mixing insulin with and its transfusion as in the clinical treatment were imitated.The experiment was divided into 8 groups： glass bottles and plastic bottles.And each group was further divided into another 2 groups according to the different operation： transfusion or adsorption.By the UV spectroscopy,in the transfusion group,the insulin concentration of the sample taken after each 50 mL of the mixed solution droped was monitored.According to the different solvent,the adsorption group was divided into 3 groups： NaCl Group,50 g/L glucose group and 100 g/L glucose every 10 minutes and to detect the concentration of insulin.The results show that the group.It was shaken adsorption curve was similar between different infusion sets and different menstruums.The adsorption quantity of the plastic bottle was more than glass bottles,isotonic Na chloride was more than the glucose,the 100 g/L glucose was more than the 50 g/L glucose.Therefore the loss of adsorption should be taken into consideration in the process of clinical operation.