益经消痛胶囊质量标准研究

Quality Standard of Yijing Xiaotong Capsule

目的:建立益经消痛胶囊的质量标准。方法:采用薄层色谱(TLC)法对方中当归、丹参、肉桂、延胡索进行定性鉴别;用高效液相色谱(HPLC)法测定当归中阿魏酸的含量。结果:当归、丹参、肉桂、延胡索的TLC斑点清晰、分离度好;阿魏酸的检测浓度在0.0028～0.0448μg.mL-1范围内与峰面积积分值呈良好线性关系(r=0.9999);平均回收率为98.46%,RSD=1.53%(n=6)。结论:所建标准可用于益经消痛胶囊的质量控制。

OBJECTIVE： To establish the quality standard of Yijing xiaotong capsules. METHODS： The constituents of Angelica sinensis, Salvia miltiorrhiza, Cinnamomum cassia and Corydalis yanhusuo in Yijing xiaotong capsules were identified by TLC; and the content of ferulic acid in A. sinensis was determined by HPLC. RESULTS： The TLC spots of A.sinensis, S.miltiorrhiza, C.cassia and C.yanhusuo were all distinctive and well-separated. The calibration curve was linear for ferulic acid in the range of 0.002 8--0.044 8 μg·mL^-1（ r = 0.999 9） and its average recovery was 98.46% （RSD = 1.53%, n = 6）. CONCLUSION： The established standard is suitable for the quality control of Yijing xiaotong capsule.