天门冬化学成分的分离与鉴定

Isolation and identification of chemical constituents from the rhizome of Asparagus cochinchinensis

目的对中药天门冬(Asparagus cochinchinensis(Lour.)Merr.)的化学成分进行研究。方法采用硅胶柱色谱、制备薄层色谱、重结晶等方法进行分离纯化,通过理化性质和核磁共振波谱数据鉴定化合物结构。结果分离得到8个化合物,分别鉴定为(+)-4′-O-methyl-nyasol(1)、(+)-nyasol(2)、5,7-二羟基-6,8,4′-三甲氧基黄酮(5,7-dihydroxyl-6,8,4′-trimethoxylflavone,3)、菝葜皂苷元(sarsasapogenin,4)、5-羟甲基糠醛(5-hydroxymethylfuraldehyde,5)、β-谷甾醇(β-sitosterol,6)、胡萝卜苷(daucosterol,7)和豆甾醇(stigmasterol,8)。结论化合物3为首次从天门冬属中分离得到,化合物1、8为首次从该植物中分离得到。

Objective To isolate and identify the chemical constituents from the 95% ethanol extract of the rhizome of Asparagus cochinchinensis（ Lour. ） Merr. Methods The compounds were isolated by chromatography on silica gel and TLC. The structures of the isolated compounds were identified by analysis of their spectral data and chemical properties. Results Eight compounds were isolated from Asparagus cochinchinensis（ Lour. ）Merr. and their structures were identified as（ ＋ ）-4＇-O-methylnyasol（ 1 ）, （ ＋ ）-nyasol（2） ,5,7- dihydroxyl-6,8,4＇-trimethoxylflavone （3）, sarsasapogenin （ 4 ）, 5-hydroxymethylfuraldehyde （ 5 ） ,β-sitosterol （ 6）, daucosterol （7） and stigmasterol （8）. Conclusions Compound 3 is isolated from this genus for the first time, and compounds 1 and 8 are isolated from this plant for the first time.