奥美拉唑治疗溃疡性结肠炎80例临床观察

The clinical observation of Omeprazole in the treatment of 80 cases with ulcerative colitis

目的:研究奥美拉唑联合柳氮磺胺吡啶治疗轻中型溃疡性结肠炎的临床疗效。方法:对照组40例采用柳氮磺胺吡啶治疗,治疗组采用奥美拉唑、柳氮磺胺吡啶联合治疗,疗程为2周,观察疗效及不良反应。结果:治疗组总有效率为90.0%,不良反应发生率为2.5%;对照组总有效率为72.5%,不良反应发生率为35.0%,两组比较,均有显著性差异(P<0.05)。结论:奥美拉唑联合柳氮磺胺吡啶治疗轻中型溃疡性结肠炎疗效确切,不良反应少,适于临床使用。

Objective： To study the clinical effect of Sulfasalazine and Omeprazole in the treatment of medium-sized ul cerative colitis. Methods： The control group （40 cases） treated by Sulfasalazine, the treatment group treated by Sulfasalazine and Omeprazole. The therapeutic course was 2 weeks, observed the efficacy and adverse reactions. Results： The total effective rate of treatment group was 90.0%, the adverse reaction rate was 2.5%; the total effective rate of control group was 72.5%, the adverse reaction rate was 35.0%; there were significantly difference in the two groups （P〈0.05）. Conclusion： Omeprazole combined with Sulfasalazine in the treatment of mild ulcerative colitis medium is effective and less adverse reactions, suitable for clinical use.