氨基磺酸做催化剂催化多组分反应合成β-Acetamido Ketones(英文)

Using Sulfamic Acid as a Catalyst for the Multi-component Coupling Synthesis of β-Acetamido Ketones

氨基磺酸作为一种可回收、绿色催化剂在室温下能高效地催化合成β-乙酰氨基酮。反应产物通过红外、1H NMR和13C NMR表征,其结果证明为合成的目标分子.特别值得强调的是二元官能团的β-乙酰氨基酮也可通过乙酰氯、苯乙酮、间苯二甲醛和腈类化合物交联得到.而且二元官能团的β-乙酰氨基酮的催化合成很少见报导.在氨基磺酸催化的酮、芳醛、乙酰氯和乙腈参与的多组分反应体系中,反应有条件温和、产率较高、催化剂用量少、催化剂可以回收再利用等优势.

An efficient and improved procedure for the synthesis of β-acetylamino ketones is developed using sulfamic acid as a reusable, green catalyst at room temperature. In particular, hi-functional groups β-acetylamino ketones were first synthesized from acetyl chloride, acetonitrile, acetophenone and isophthalic aldehyde within our present learning. In this system, the catalyst is disclosed as inexpensive, recoverable and recyelable for the synthesis of β-acetamido ketones.