分蘖葱头中含氮化合物的分离与鉴定

Isolation and identification of nitrogen-containing compounds from the bulbs of Allium cepa L. var. agrogatum Don.

目的研究分蘖葱头中的非挥发性成分。方法用硅胶和凝胶柱色谱进行分离,根据理化性质和波谱特征鉴定结构。结果从分蘖葱头的乙酸乙酯和正丁醇萃取部分中分离得到两个含氮化合物,分别鉴定为N-反式-对羟基苯乙基香豆酰胺(Ⅰ)和1,6-己内酰胺(Ⅱ)。结论化合物Ⅰ和Ⅱ均为首次从分蘖葱头中分离得到的单体,其中化合物Ⅱ为首次从植物中分离得到。

Aim To study the non-volatile constituents from the bulbs of Allium cepa L.var.agrogatum Don.Methods The compounds were isolated by repeated silica gel and Sephadex LH-20 chromatographies,and their structures were elucidated on the basis of physicochemical properties and spectroscopic analysis.Results Two nitrogen-containing compounds were isolated from the EtOAc and n-BuOH layers,respectively.They were identified as N-trans-p-hydroxyphenethyl coumaramine（Ⅰ）and 1,6-hexanolactam（Ⅱ）.Conclusion Compounds Ⅰ and Ⅱ were isolated from this plant for the first time.Compound Ⅱ was isolated from the natural products for the first time.