抗结核药物作用机制及构效关系的研究进展

Research advances on the activity mechanism and structure-activity relationships of anti-tuberculosis agents

在过去的几十年里,随着艾滋病(AIDS)的蔓延,结核病的发病率也在逐渐增多,除结核病外,由分支杆菌所引起的其他疾病也开始传播,HIV感染患者特别容易受分支杆菌的感染。该文主要对抗结核药物的作用机制以及构效关系(SARs)进行简要的综述,以便能更好的、合理的使用抗结核药物。

In the past few decades,with the prevalence of AIDS,tuberculosis has begun to comeback and spread.In addition to tuberculosis,diseases caused from Mycobacterium also began to become more prevalent,HIV-infected patients were particularly vulnerable to mycobacterial infections,incidence rate of such diseases and the resulting burden is very argent in the global.The mechanism and structure-activity relationships（SARs） of anti-tuberculosis agents were briefiy reviewed.