乙肝患者血清前S1抗原和乙肝血清标志物联合检测的意义

Clinical significance of combined measurement of PreSl antigen and HBV serological markers in patients with hepatitis B

目的探讨乙肝患者血清前S1抗原与HBV 5项之间的相关性及临床意义。方法采用ELISA法对268例乙肝患者进行血清前S1抗原的检测。结果前S1抗原在HBeAg阳性标本中检出率为85.88%,在阴性标本中的检出率为39.34%,两者比较差异有统计学意义,P<0.01。结论前S1抗原能较好地反映乙肝病毒的复制情况。在临床检验中,对乙肝患者血清进行前S1抗原与乙肝三系统联合检测,将有助于临床诊断、疗效观察及预后判断。

Objective To investigate the relationship between PreS1 antigen and five items of HBV serological markers（HBV M）, as well as the clinical significance of combined measurement of PreS1 antigen and HBV M in patients with hepatitis B. Methods Enzyme linked immunosorbent assay （ELISA） was applied to testing serum in 268 patients with hepatitis B. Results The detection rate of PreS1 antigen was 85.88% in HBeAg positive samples,significantly higher than that in HBeAg negative samples（39.34%）, P〈0. 01. Conclusion PreS1 antigen may effectively reflect the situation of HBV amplification. Combined measurement of PreS1 antigen and HBV serological markers in clinical examination contributes to clinical diagnosis, therapeutic effect monitoring and prognosis evaluation.