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EGFR信号通路基因突变与非小细胞肺癌的靶向性治疗 被引量：5

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摘要 表皮生长因子受体(EGFR)是酪氨酸激酶活性的受体,由配体激活后,调解上皮细胞的生长分化。近年来研究发现有62%的非小细胞肺癌患者存在EGFR高表达和异常激活。针对EG-FR突变研发的靶向治疗药物——吉非替尼、埃罗替尼已通过美国FDA验证用于临床,但是存在不同程度的耐药。可见,决定非小细胞肺癌(NSCLC)对酪氨酸激酶受体抑制剂(TKI)——Gefitinib,Erlotinib敏感性的突变基因不仅仅只有EGFR基因,其存在复杂的基因突变谱。本文就目前对NSCLC基因突变类型与靶向治疗的研究进展作一综述。
作者 潘虹 黄庆 府伟灵
机构地区 第三军医大学西南医院检验科
出处 《国际检验医学杂志》 CAS 2009年第9期869-871,共3页 International Journal of Laboratory Medicine
基金 重庆市科技攻关计划项目(2007AC5067)
关键词 癌 非小细胞肺 受体 表皮生长因子 信号传导 突变
分类号 R734.2 [医药卫生—肿瘤] R730.5 [医药卫生—肿瘤]
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参考文献13

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二级参考文献69

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共引文献44

同被引文献48

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引证文献5

二级引证文献10

国际检验医学杂志
2009年 第9期

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