超敏C反应蛋白与血脂联合检测在冠心病中的临床价值

Clinical value of combined detection of high sensitive C reactive protein and blood lipids in coronary heart disease

目的观察冠心病(CHD)患者超敏C反应蛋白(hs-CRP)、血脂水平的变化,及其在CHD危险性评估中的临床价值。方法用免疫透射比浊法和酶法分别测定稳定型心绞痛(SAP)患者51例,不稳定型心绞痛(UAP)患者44例,急性心肌梗死(AMI)患者40例和健康者45例的hs-CRP和血脂。结果相对健康对照组,SAP、UAP、AMI三组的hs-CRP均有升高,UAP、AMI组与健康对照组的hs-CRP值相比差异有统计学意义(P<0.05),但SAP组与健康对照组比较差异无统计学意义(P>0.05)。hs-CRP与总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B、脂蛋白a(LPa)呈显著正相关(P<0.05),与高密度脂蛋白胆固醇、载脂蛋白A1呈显著负相关(P<0.05)。结论hs-CRP可辅助CHD的诊断,与血脂联合检测对CHD的危险性评估及预后判断有重要价值。

Objective To observe the changes of high sensitive C reactive protein（hs-CRP） and blood lipids,and investigate the clinical value of combined detection of the above markers in evaluating the risk and prognosis of coronary heart disease（CHD）. Methods Totally 51 cases of stable angina pectoris（SAP group）,44 cases of unstable angina pectoris（UAP group）,40 cases of acute myocardial infarction（AMI group） and 45 healthy controls（bealthy control group） were enrolled in the investigation. Hs-CRP and blood lipids were measured with enzymic method and irnmunoturbidimetry respect ively. Results The level of hs-CRP was significantly higher in UAP group and AMI group than that in healthy control group（both P〈0. 05）. Hs-CRP level was a little higher in SAP group than that in healthy control group,but there was no statistical difference（P〉0.05）. In addition,hs-CRP was positively correlative with total chotesterol（TC） ,low density lipoprotein-cholesterol（LDL-C）, apoprotein B （apoB） and lipoprotein a（LPa）（P〈0.05）, and negatively correlative with high density lipoproteincholesterol（HDL-C） and apoAI（P〈0.05）. Conclusion Hs-CRP contributes to diagnosis of CHD,and combined detection of hs-CRP and blood lipids is of important value in evaluating the risk and prognosis of CHD.