高脂血症相关性急性胰腺炎临床研究

Clinical study on hyperlipidemic - acute pancreatitis

目的探讨高脂血症尤其是高甘油三酯血症（HTG）与急性胰腺炎的关系。方法回顾性分析15例高脂血症伴急性胰腺炎（HL—AP）患者临床特点和脂肪肝、高脂血症与急性胰腺炎之间的关系。结果高脂血症相关性急性胰腺炎常不伴有血、尿淀粉酶的明显升高；与其他原因所致急性胰腺炎相比，其脂肪肝、糖尿病发病率明显升高（P〈0．05）；且重型急性胰腺炎较轻型急性胰腺炎的高密度脂蛋白（HDL）下降更为明显（P〈0．05）。结论高脂血症，尤其是HTG和急性胰腺炎之间具有密切的相关性，HTG是引起急性胰腺炎的独立危险因素；HDL下降可作为预示HL—AP重症的指标之一。

Objective To explore the correlation ship between acute pancreatitis（AP） and hyperlipidemia（ HL）, especially hypertrglyceridemia（HTG）. Methods A retrospective analysis of 15 AP patients with HL was carried out to detect the correlation ship between AP and fatty liver and HL. Results The elevation of blood and urine amylase was not fre- quently remarkable in hyperlipidemic - acute pancreatitis （ HL - AP ）. Compared with other pattern of AP, HL - AP had higher incidence of fatty liver and diabetes（ P 〈0.05 ）. The decrease in high -density lipoproteins（HDL） was significantly more in patients with severe acute pancreatitis（ SAP） than that in those with mild acute pancreatitis（MAP） （ P 〈 0.05 ）. Conclusions Serum HTG bears closely correlation to AP, and is an independent dangerous factor for AP. A decrease of HDL level may be taken as one of the markers for predicting the severity of HL - AP.