摘要
1997年10月~1998年3月,从北京青年中分离到6株H1N1流感亚型毒株,经国家流感中心鉴定确认。将6株中的5株与1994~1997年3株(H1N1)国家代表株作血凝抑制交叉试验,5株的抗原性明显不同于A/桂防/10/94,抗原比均≥2。5株中的4株抗原性明显不同于A/京防/25/96;5株中的2株抗原性明显不同于A/京防/53/97。将6株H1N1流行株送日本WHO流感协作中心作多株H1N1毒株抗原性初步分析,6株抗原性既不同于A/日本山形/120/86和A/日本山形/32/89,也不同于国际代表株德国的A/拜恩州/07/95和南非的A/约翰内斯堡/82/96。表明H1N1流感亚型毒株自1994年以来抗原变异较大。
Six strains of flu-A(H 1N 1),isolated from young people in Beijing zone from Oct.1997 to Mar. 1998, were identified by National Center of lnfluenza Surveillance. Five of the 6 strains were performed haeamoglutinin inhibition test (HIA), compared with national strains of H 1N 1 among 1994 and 1997. We found that antigenicity of the 5 strains was significantly different from that of A/Guifang/10/94(antigenic ratio≥2). Antigenicities of 4 and 2 among the 5 strains were significantly distinctive with A/Jingfang/25/96 and A/Jingfang/53/97, respectively. We also sent the 6 strains to WHO Influenza Cooperation Center in Japan to analyze their antigenicities. They were different either from those of A/Yamagata/120/86 and A/Yamagata/32/89 or from the international flu strains:A/Bayern/07/95 and A/Johannesburg/82/96. Thus, it is concluded that antigenicity of H 1N 1 has varied so greatly since 1994 that it is necessary to surveille it rigorously
出处
《解放军预防医学杂志》
北大核心
1998年第6期423-426,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
总后"九五"课题资助项目
关键词
甲1型流感病毒
抗原性分析
分离
流感病毒
influenza-A(H 1N 1)
antigenic analysis
haeamoglutinin inhibition test