维生素D研究进展

Progress of Vitmin D Research

维生素Ｄ与甲状旁腺激素和降钙素共同组成体内钙代谢的主要调节系统。特别是对维持血钙平衡，维生素Ｄ起着关键作用。作者曾在１９８６年于本刊发表一篇有关维生素Ｄ研究进展的综述。时过１２年后，维生素Ｄ的研究在许多方面又取得很大进展，现作部分简介。一、１，２５一...

Vitamin D is one of the primary regulators of Calcium homeostasis in the body and in criticaly important for the normal mineralization of bone. l, 25(OH) 2D 3 is produced by sequential hydroxylations of vitamin D in the liver and in the kidney. The Classical target organs of 1, 25 (OH) 2D 3 are intestine,bone and kidney. A plethora of tissues to possess receptors to 1, 25 (OH) 2D 3. Vitamin D has many additional functions, such as immunosuppression, stimulates cell differetiation. and inhibits cell proliferation. The VDR genotype hypothesis remains controversial, using subjects of different ethnic background, have or not found a similar correlation hetween the different VDR alleles and bone density. Many 1, 25 (OH) 2D 3 analogs have heen synthesized , some of which were found to be more potent than 1, 25 (OH) 2D 3, at inhibiting tumor growth and less likely to induce hypercalcemia.