青州市小儿格林-巴利综合征流行病学特点与临床分析

The epidemiological characters and clinical analysis ofGuillain-Barre' syndrome in children of Qingzhou

目的探讨小儿格林-巴利综合征（GBS）病因、发病机制、防治措施。方法对青州市242例GBS患儿进行回顾性流行病学调查、临床观察、免疫学检测及微量元素检测。结果242例GBS患儿52．81％发病年龄为3～6a，75．61％发病时间在7～9月份，98．7％来自农村，年发病数3～40例，52．17％血清抗神经抗体阳性，平均血清锌含量9．12±0．56μmol／L。补锌治疗可促进康复。结论青州市小儿GBS发病年龄、季节、区域、年发病数有明显差异，患儿存在免疫紊乱及微量元素锌缺乏。

To explore the cause of the Gullain-Barre' syndrome(GBS) in children and the pathogenesis, summarize the expeliencesin prevention and therapy.Methods The investigators made clinical observation on the 242children with GBS and made a epidemiological retrospective investigation.Results 52. 81 % of the 242 cases of GBS took place at the age ofthree to six years old. and 75. 61 % of them during the course of Julyto september. 98. 7% of the children were from the countryside.1. 3% of them from city. The anti-nerve antibody was positive in52. 17% of them. The aver age density of serum zine was 9. 12±0. 5μmol/L (lower than the normal, P<0. 01).Conclusions It has obvious difference at the age. season and region of invation in children of Qingzhou. The patients from the countryside were more than the ones from foe city. The pathogenesis isassociated with the immune disorder. The deficiency of zine. the traceelement .is one of the factors related ic the immunc disorder.