国产美托洛尔静脉制剂控制阵发性心房颤动时快速心室反应的疗效评价

Metoprolol for Ventricular Rate Control of Paroxysmal Atrial Fibrillation

目的：研究国产美托洛尔静脉制剂用于控制阵发性心房颤动时快速心室率的效果。方法：３３例阵发性心房颤动患者分别接受了静脉美托洛尔（美托洛尔组，１６例）和毛花甙Ｃ（毛花甙Ｃ组，１７例）治疗。结果：１６例接受静脉美托洛尔５ｍｇ治疗的患者用药３０分钟后心室率从１２８±２１次／分降至９０±１８次／分（Ｐ＜０００１）；接受静脉毛花甙Ｃ０．４ｍｇ至０．６ｍｇ治疗者用药３０分钟后的心室率从１３４±１７次／分降至１０８±１７次／分（Ｐ＜００１）；用药３０分钟后美托洛尔组心率明显慢于毛花甙Ｃ组（Ｐ＜００１），而与毛花甙Ｃ组６小时后的心室率相当（８４±１８次／分，Ｐ＞００５）。两组患者用药前后的血压无明显变化。所有患者都没有因为药物副作用而终止试验。

Objective:To examine the efficacy and safety of intravenous metoprolol in controlling ventricular rate of paroxysmal atrial fibrillation. Methods:Thirty three patients were enrolled in either intravenous metoprolol group(16 cases) or intravenous lanatoside C(cedilanid)group (17 cases). Results:The heart rate of metoprolol group decreased from 128±21 beats/min to 90±18 beats/min( p <0.001)in 30 minutes after 5 mg metoprolol administration.The heart rate of cedilanid group decreased from 134±17 beats/min to 108±17 beats/min 30 minutes and 84±18 beats/min 6 hours after 0.4 mg to 0.6 mg cedilanid administration.The ventricular rate control after 30 minutes of metoprolol administration was more effective than 30 minutes after and equally effective as 6 hours after cedilanid administration.No patients stopped study because of side effects. Conclusion:Intravenous metoprolol is safe and effective in controlling ventricular rate of paroxysmal atrial fibrillation.