在肾动脉下方的腹主动脉上犬同种带瓣主、肺动脉移植模型

A Canine Model of Infrarenal Conduit Valved Homograft Transplatation

目的：建立在肾动脉下方的腹主动脉上犬同种带瓣主、肺动脉移植实验模型，以研究其移植后免疫学、组织活性和超微结构改变以及宿主细胞替换供体组织过程。方法：将犬分为４组，采用犬同种带瓣主、肺动脉沿血流方向移植于异性受体犬肾动脉下方的腹主动脉上的方法。结果：全组２８例均存活，满足实验设计要求。结论：本实验模型具有手术操作容易、成功率高、术后并发症少。

Objective:To establish a canine model of conduit valved homograft being implanted into the infrarenal abdominal aorta so as to study the immune response,the cell viability and ultrastructure of donors and the process of host cells repopulating donor tissues. Methods:Canine conduit valved homograft was heterotopic transplanted along the orientation of the blood stream into the infrarenal abdominal aorta of the recipient canine whose sexuality was different from the donor. Results:All of the 28 cases were alive and could fully meet the needs of the experimental design. Conclusion:This experimental model has the adventages of easy being operated,low postoperative complication and low experimental cost.