血清巨噬细胞集落刺激因子与冠状动脉病变程度的相关性研究

Study of association between the serum level of macrophage colony stimulating factor and severity of coronary artery disease

目的探讨冠心病患者巨噬细胞集落刺激因子(M-CSF)与冠状动脉病变程度的关系。方法选择心内科行冠状动脉造影的患者共241例,根据冠状动脉造影结果分为冠状动脉狭窄组(n=135)与非狭窄组(n=106)。比较冠状动脉狭窄组与非狭窄组以及不同病变支数患者的血清M-CSF水平,分析M-CSF与冠状动脉病变程度的相关性。结果冠状动脉狭窄组冠状动脉狭窄评分、血清M-CSF浓度高于非狭窄组,且随着狭窄支数的增加而逐渐增高,尤其以3支病变患者更为显著(P<0.01)。Pearson直线相关分析显示,年龄、糖尿病史、吸烟、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、M-CSF与冠状动脉病变支数呈正相关(r分别为0.325、0.241、0.227、0.087、0.053、0.385、0.414,均P<0.05)。结论M-CSF参与冠状动脉粥样硬化,与冠状动脉病变程度呈正相关;M-CSF增高是冠心病发病及进展的独立预测因子。

Objective To determine the influences of macrophage colony stimulating factor （M-CSF） on severity of coronary artey stenosis （ CAS）. Methods 241 subjects underwent coronary artery angiography were included in the study, and they were divided into two groups according to the results of coronary artery angiography. One group was the patients with coronary artey stenosis, and the other group was those without coronary artey stenosis. The serum level of M-CSF were compared between two groups. Then the associations between the level of M-CSF and the severity of coronary artery stenosis were analyzed among the groups. Results The level of M-CSF in serum of subjects with coronary stenosis was significantly higher than subjects without coronary stenosis , especially more significantly in the patients with three-branch lesion（ P 〈 0.01 ）. Pearson linear correlational analysis showed that age, diabetes mellitus history, smoke, TC, LDL-C and the serum level of M-CSF positively correlated with the number of CAS （r = 0. 325, 0. 241, O. 227,0. 087,0. 053, 0. 385,0. 414, all P 〈 0.05 ）. Conclusion The serum level of M-CSF was posositively correlated with the severity of CAS. The serum level increasing of M-CSF is an independent predictor for CAS.