乳腺癌患者CerbB-2表达和组织激素受体、淋巴结转移的关系

Relationship between the express of CerbB-2 and estrogen receptor,progesterone receptor,lymph node metastasis in breast cancer

目的探讨乳腺癌患者CerbB-2的表达情况及其与雌激素受体(ER)、孕激素受体(PR)、淋巴结转移及患者年龄的关系。方法回顾分析675例乳腺癌患者ER、PR及CerbB-2的表达情况,分析CerbB-2表达与ER、PR表达及与淋巴结转移的关系。结果CerbB-2过表达者比CerbB-2低表达者ER阳性率低(45.92%vs70.40%,P<0.01),PR阳性率低(62.24%vs73.3%,P<0.01),腋窝淋巴结转移率高(45.35%vs43.46%,P<0.01);CerbB-2过表达患者中70岁及以上者比例低于CerbB-2低表达患者(1.02%vs7.37%,P<0.05)。结论CerbB-2过表达的乳腺癌患者ER、PR表达率更低,淋巴结转移率更高,侵袭性更强,预后更差。

Objective To explore the relationship between the expression of CerbB-2 and estrogen receptor （ER）, progesterone receptor （PR）, lymph node metastasis in breast Cancer. Methods The clinical and pathology data from 675 breast neoplasms of women aged from 25 to 79 years were analyzed retrospectively according to the relationship between the expression of CerbB-2 and ER,PR,lymph node metastasis and age. Results In the group of tumor tissue with CerbB-2 overexpressed,the positive rates of ER was lower than that of the other group（P 〈 0. 01 ）, the positive rate of PR was lower than that of the other group （P 〈 0. 01 ）, The rate of lymph node metastasis was higher than that of the other group（P 〈 0.01 ）, the rate of people aged more than 70 years was lower than that of the other group （P 〈 0.05 ）. Conclusion Breast cancer patient with CerbB-2 overexpressed has lower expression of ER, PR, higher rate of lymph node metastasis and bad prognostic profile.