牧马豆生物碱成分研究

Alkaloids from Lanceleaf Thermopsis (Thermopsis lanceolata)

从豆科野决明属植物牧马豆ThermopsislanceolataR.Br.的全草中分得6个生物碱。经物理常数测定及光谱分析，分别鉴定为黄华碱（Ⅰ），13-羟基黄华碱（Ⅱ），金雀花碱（Ⅲ），N-甲基金雀花碱（Ⅳ），5，6－dehydrolupanine（Ⅴ）和N－（3－氧代丁基）金雀花碱（Ⅵ）。其中化合物Ⅱ和Ⅴ为首次从该植物中分得，化合物Ⅵ为首次从本属植物中分得。

Six quinolizidine-type alkaloids were isolated from the whole plant of Thermopsis lanceolata R.Br.. They were thermopsine(Ⅰ), 13β-hydroxylthermopsine(Ⅱ), cytisine(Ⅲ), N-methylcytisine(Ⅳ),5, 6-dehydrolupanine(Ⅴ) and N-(3-oxobutyl) cytisine (Ⅵ) respectively. Compound Ⅱ and Ⅴ were obtained from. this species for the first time while compound Ⅵ was isolated for the first time from genus Thermopsis. All structures were elucidated on the basis of physico-chemical contants and spectroscopic evidences.