人和小鼠NK细胞亚群划分的共同标志的发现:CD27分子

Common phenotypic molecule for classification of NK cell subsets of both human and mouse:CD27 molecule

依据CD27表达与否可将小鼠NK细胞划分为CD27hiNK细胞和CD27loNK细胞二个亚群;CD27与CD11b联合,可以进一步将小鼠NK细胞划分为四个亚群:CD11bloCD27lo、CD11bloCD27hi、CD11bhiCD27hi和CD11bhiCD27lo。不同的NK细胞亚群处于不同的发育分化阶段,表型与功能也均各具特点。小鼠NK细胞沿着CD11bloCD27lo→CD11bloCD27hi→CD11bhiCD27hi→CD11bhiCD27lo路径发育分化。CD27也可以对人NK细胞亚群进行划分,并可与小鼠NK细胞生物学功能进行更精确的比较。

NK cells can be divided into two subsets based on CD27 expression：CD27hiNK cells and CD27loNK cells. NK cells can be further divided into four subsets based on CD27 and CD11bhiCD11 bloCD27lo, CD11bloCD27hi, CD11biCD27hi and CD11bhiCD27lo. These subsets in different development stages have their own phenotypes and functions. In mice, NK cell developing pathway is through CD11bloCD27lo→CD11blo-CD27hi→CD11bhiCD27hi→CD11bhiCD27lo CD27 can also be used to divide human NK cells into two subsets which are comparable to those of mice