低分子肝素治疗重度子痫前期作用的研究

Study of low molecular weight heparin on severe pre-eclampsia

目的探讨低分子肝素在治疗妊娠期高血压疾病重度子痫前期中的作用。方法选取妊娠期高血压疾病重度子痫前期患者48例,随机分为2组,对照组22例采用硫酸镁解痉、硝苯地平降压等方法治疗,观察组26例在对照组基础上加用低分子肝素治疗,比较2组患者治疗前后血压、全血比黏度、凝血功能指标、红细胞压积、尿量和尿蛋白、水肿、产后出血及新生儿病理性黄疸发生率。结果妊娠期高血压疾病重度子痫前期治疗中加用低分子肝素可有效地降低血压,红细胞压积下降,尿蛋白减少及尿量增加,并不增加产时及产后出血,不增加新生儿黄疸和新生儿溶血的发生。结论在解痉降压基础上加用肝素治疗重度妊娠高血压综合征较传统方法疗效更佳,且不增加药物的不良反应,值得推广。

Objective It is to approach the action of low molecular weight heparin on pregnancy hypertension disease severe pre-eclampsia. Methods 48 patients with pregnancy hypertension disease severe pre-eclampsia were randomly divided into two groups. 22 patients were in control group and treated with magnesium sulfate spasmolysis and nifedipine decompression. 26 patients were in observation group and treated with low molecular weight heparin based on control group. Blood pressure, whole blood viscosity, coagulation function index, hematocrit, urine output and urine protein, edema, postpartum hemorrhage and the incidence of neonatal pathologic jaundice in the two groups before and after treatment were compared. Results Pregnancy hypertension disease severe pre-eelampsia treated with low molecular weight heparin in prophase of treatment could effectively lower blood pressure, lower hematocrit, decrease urine protein and increase urine output, but could not increase intrapartum hemorrhage and postpartum hemorrhage and the incidence of neonatal jaundice and neonatal hemolysis. Conclusion The curative effect of heparin on pregnancy hypertension disease severe pre-eclampsia based on spasmolysis and decompression is better than traditional method and can not increase untoward reaction of drugs, which is worth generalization.