生血微丸胶囊质量标准的研究

Quality standard of Shengxue Micro Capsules

目的：制定生血微丸胶囊（绿矾、肉桂、海螵蛸、阿胶、紫河车）的质量标准。方法：用理化方法对生血微丸胶囊中绿矾、海螵蛸进行鉴别,用薄层色谱法对生血微丸胶囊中肉桂进行鉴别,用紫外分光光度法对生血微丸胶囊中绿矾的Fe-SO4进行含量测定,用气相色谱法对生血微丸胶囊中桂皮醛进行含量测定。结果：理化方法能检出绿矾、海螵蛸;在薄层色谱中能检出肉桂;紫外分光光度法测得FeSO4在0～20 mg/L范围内具有良好的线性关系（r=0.999 8）,平均回收率为96.7%（n=5）;气相色谱法测得桂皮醛其峰面积与进样量在0.157 5～0.551 4μg范围内呈良好线性关系（r=0.999 8）,平均回收率为101.52%。结论：该方法准确、灵敏,重复性好,能有效地控制生血微丸胶囊的质量。

AIM： To establish the quality standard for Shengxue Micro Capsules （melanteritum, Cortex Cinnamo-mi , Endoconcha Sepiae , Colla Corii asini , Placenta Hominis ） . METHODS ： The melanteritum, Endoconcha sepiae was identified by physic-chemical analysis. Cortex Cinnamomi was identified by TLC. UV was employed for the assay of FeSO4. GC was used to determine Cinnamaldehyde of Shengxue Micro Capsules. RESULTS ： Green vitriol, Endoconcha sepiae could be identified by physico-chemical analysis. Cortex Cinnamomi could be identified by TLC. The linear range of FeSO4 was within 0 - 20 mg, r = 0. 999 8 ; The average recovery of assay was 96.7%. The linear range of cinnamaldehyde was within 0. 157 5 -0. 551 4 μg, r = 0. 999 8; The average recovery of assay was 101.52%. CONCLUSION： The method is simple, reproducible. It could be used for quality control of Shengxue Micro Capsules.