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MDR3、FXR基因在肝内胆汁淤积的遗传学研究进展 被引量：1

Genetics Research of Multidrug Resistance Protein 3,Farnesoid X Receptor Gene in Intrahepatic Cholestasis
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摘要 肝内胆汁淤积的发病机制复杂,目前仍不十分清楚。有研究认为遗传因素扮演着重要的角色,进行性家族性肝内胆汁淤积已证实由基因突变引起,胆汁的分泌过程由多个胆汁相关性基因调控。而法尼醇受体基因(FXR)对胆汁分泌的间接调控及其所形成的复杂网络,使其成为近几年胆汁淤积方面的研究热点之一。 The etiology and pathogenesis of intrahepatic cholestasis are complex, and those are not still very clear in current. Studies suggest that genetic factors play an important role in the pathogenesis of the disease. Some familial cholestasis have been confirmed by gene mutation causing. Bile secretion process regulated by a number of bile relation gene at the molecular level. Farnesoid X receptor （FXR） gene is related to intrahepatic bile secretion process. Bile secretion is indirect control by FXR which formats a complex network, becoming more attention to researcher in recent years.
作者 陈秀奇 王琳琳
机构地区 广西医科大学第一附属医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2009年第19期1527-1529,共3页 Journal of Applied Clinical Pediatrics
基金 广西科学研究与技术开发计划项目资助(桂科攻0816004-6)
关键词 胆汁淤积 多药耐药蛋白3 法尼醇受体基因 intrabepatic cholestasis muhidrug resistance protein 3 farnesoid X receptor gene
分类号 R725.7 [医药卫生—儿科]
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参考文献26

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同被引文献16

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  • 3Misawa T,Hayashi H,Makishima M,et al.E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064:structural development study and separation from farnesoid X receptor-agonistic activity.Bioorg Med Chem Lett 2012,22(12):3962-3966.
  • 4Plass JR,Mol O,Heegsma J,et al.Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.Hepatology 2002,35(3):589-596.
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  • 6Cui YJ,Aleksunes LM,Tanaka Y,et al.Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.Toxicol Sci 2009,110(1):47-60.
  • 7Jittima Weerachayaphorn,Shi-Ying Cai,Carol J.Soroka,and James L.Boyer.NF-E2-related factor 2 (Nrf2) is a positive regulator of human bile salt export pump (BSEP) expression.Hepatology 2009,50(5):1588-1596.
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  • 10Hayashi H,Sugiyama Y.Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).Mol Pharmacol 2009,75(1):143-150.

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实用儿科临床杂志
2009年 第19期

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