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茶碱缓释片药物释放影响因素研究 被引量:2

Reseach on the factors affecting the releasing medicine of theophylline sustained - release Tablets
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摘要 目的:制备茶碱缓释片剂,考察高分子缓释材料及片剂硬度对其释放度的影响。方法:调节乙基纤维素与羟丙甲纤维素的配比,制备不同的缓释片剂;再用优选配比的同一批颗粒分别压制成不同硬度的缓释片剂,测定其释放度。结果:缓释材料的配比不同,缓释片的释放度也不同,但片剂硬度不影响缓释片的释放度。结论:优选配比所制备的片剂,体外释药性能良好,适合于工业化生产。 OBJECTIVE: To prepare theophylline sustained-release tablets, examine the high polymer sustained-release materials and the hardness of the tablets effect on the releasing degree. METHODS: To adjust the proportion of EC and HPMC,prepare different sustained - release tablets;then prepare sustained - release tablets of different hardnesses of the same grains with choiced proportion, and measure their releasing degree. RESULTS: If the proportion of sustained -releasing materials are different, the releasing degree of sustained - releasing tablets are also different. But the hardnesses of tablets do not affect releasing degree of sustained - releasing tablets. CONCLUSION: To prepare the tablets with choiced proportion,the releasing character is fine in vitro,they are suitable for industrial production.
机构地区 湘潭市制药三厂
出处 《中国现代应用药学》 CAS CSCD 1998年第6期31-32,共2页 Chinese Journal of Modern Applied Pharmacy
关键词 茶碱 缓释片 释放度 药物释放 theophylline, sustained - releasing tablets, prepare, hardness, releasing degree
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