川续断总生物碱对妊娠大鼠子宫的抗致痉及抗流产作用

Antispasmodic and Antiabortifacient Effects of Total Alkaloids from Dipsacus asperoides on Pregnant Rats

本研究表明川续断总生物碱能显著抑制妊娠大鼠在体子宫平滑肌的自发收缩活动，降低其收缩幅度和张力；对抗0．25U·kg－1催产素诱发的妊娠大鼠在体子宫收缩幅度和张力的增加；并具有对抗大鼠摘除卵巢后导致的流产作用。

Total alkaloids extracted from Dipsacus asperoides markedly inhibited the spontaneous contraction of pregnant rat uterus in vivo,and suppressed the increase of intensity,tonicity and frequency induced by Oxytoxin (0. 25 U/kg) in pregnant rat uterus in vivo. Total alkaloids also antagnized abortion of rats induced by removal of ovary.