ER、PR及PCNA在子宫内膜增生过长和内膜腺癌中的表达

Expression of Estrogen Receptor, Progesterone Receptor and Proliferating Cell Nuclear Antigen in Hyperplasia and Adenocarcinoma of Endometrium

为了探讨女性激素在子宫内膜腺癌和子宫内膜增生过长发病中的作用，为临床内分泌治疗提供理论依据，作者采用免疫组织化学ＳＰ法，对手术切除和诊刮的１７例子宫内膜腺癌和４０例子宫内膜增生过长标本进行ＥＲ、ＰＲ和ＰＣＮＡ含量检测，并结合组织学类型和分化程度进行分析。结果显示内膜腺癌组织中ＥＲ、ＰＲ的含量低于增生期和增生过长内膜组织（Ｐ＜０．０５），与肿瘤的组织学类型和分化有关。ＰＣＮＡ在子宫内膜腺癌中的含量显著高于非肿瘤性内膜组织（Ｐ＜０．０１），与分化程度呈负相关。与ＥＲ、ＰＲ的含量无明显相关性。结果表明ＥＲ在子宫内膜增生过长和内膜腺癌的发病中起重要作用，ＰＣＮＡ的过度表达可能与细胞的异常生长和分化有关。

In order to investigate the role of female sex steroid hormones in the pathogenesis of endometrial adenocarcinoma and endometrial hyperplasia and provide theoretical basis for endocrine therapy,the contents of estrogen receptor (ER),progesterone receptor (PR),and proliferating cell nuclear antigen (PCNA) were determined by immunohistochemical SP method in specimens of endometrial adenocarcinoma (17 cases) and endometrial hyperplasia (40 cases) obtained by hysterctomy and biopsy respecitively the results showed that the contents of ER and PR were significantly lower in endometrial adenocarcinoma than those in the proliferative phase and endometrial hyperplasia (P<0.05) and were related to histologic type and degree of tumor differentiation.The contents of PCNA in adenocacinoma of endometrum were significantly higher than those in the nonneoplastic endometrum (P<0.01),but were negatively correlated to their cell differentiation,while there was no obvious correlation between contents of ER,PR and PCNA.These findings indicate that estrogen may play an important role in pathogenesis of hyperplasia and adenocacinoma of endometrium.The overexpression of PCNA could be correlated to abnormal growth and differentiation in these tissues.