喉癌患者血浆前列环素及血栓素水平测定

Determination of Prostacyclin and Thromboxane Concentrations in the Plasma of Patients with Laryngeal Carcinomas

作者为探讨喉癌患者血浆中前列环素及血栓素的临床意义，采用放射免疫分析法测定３２例喉癌患者血浆前列环素、血栓素Ａ２稳定的降解产物６－酮基－前列腺素Ｆ１α和血栓素Ｂ２含量，并与喉部良性疾病患者及正常人作双重对照。结果表明喉癌患者血浆前列环素和血栓素Ａ２水平显著升高（Ｐ＜０．０１），它们分别是正常人的３．１７倍及３．７３倍。血浆前列环素和血栓素Ａ２与喉癌Ｔ分级皆呈正相关，前列环素相关系数为ｒ＝０．６５（Ｐ＜０．０１），血栓素Ａ２相关系数为ｒ＝０．５２（Ｐ＜０．０１）。以上结果提示喉癌组织合成并释放前列环素和血栓素Ａ２显著增加，并与喉癌Ｔ分级密切相关。

In order to study the clinical significance of prostacyclin (PGI2) and thromboxane A2(TXA2) concentrations in the plasma of patients with laryngeal carcinoma 6KetoPGF1α (a hydrolysis of PGI2) and TXB2 (a hydrolysis of TXA2) concentrations in the plasma of 32 patients with laryngeal carcinomas were determined by radioimmunoassay and compared with benign laryngeal diseases and normal subjects respectively. The results showed that 6KetoPGF1α and TXB2 concentrations in the plasma of patients with laryngeal carcinomas were significantly higher than those in the plasma of patients with benign laryngeal diseases and normal subjects (P<0.01). The values of 6KetoPGF1α and TXB2 in the plasma of laryngeal carcinomas were 3.17 times and 3.73 times as much as that in the plasma of normal subjects. The results also reveal that 6KetoPGF1α and TXB2 concentrations in the plasma of laryngeal carcinomas had positive correlation with the T category of laryngeal carcinomas, their correlation coefficient being 0.65 (P<0.01) and 0.52 (P<0.01), respectively. The findings suggest that laryngeal tissues might synthesize and release PGI2 TXA2 greatly as compared to the normals, their concentrations are close correlated with T category of laryngeal carcinomas.