恶性肿瘤患者血清sIL-2R水平及临床意义

Expression and Clinical Significance of Serum sIL2R in Patients with Cancer

作者采用ＥＬＩＳＡ夹心法对２６３例恶性肿瘤病人血清ｓＩＬ－２Ｒ进行测定。结果发现，恶性肿瘤患者血清ｓＩＬ－２Ｒ明显高于良性肿瘤和正常对照组（Ｐ＜０．０１），并与临床分期及病情的严重程度有关，伴有转移的患者血清ｓＩＬ－２Ｒ升高更为明显，与病情稳定或非转移患者相比有非常显著性差异（Ｐ＜０．０１）。作者认为，检测恶性肿瘤患者血清ｓＩＬ－２Ｒ，不但可用于了解患者的免疫状态，也能在一定程度上对疾病的严重程度、肿瘤分期、疗效及预后等作出评估。

The levels of soluble interleukin2 receptor (sIL2R) were analysed by an enzymelinked immunosorbent assay in 263 cases of patient with cancer and 66 healthy adults.The ressults showed that serum sIL2R levels of cancer group (343.5±332.6 u/ml) was significantly higher than those of healthy controls (317.1±126.5 u/ml) (P<0.001) and correlated with clinical stage and degree of disease.The patients with metastasis had even higher value than those without it (P<0.001).Therefore,it is concluded that the serum sIL2R levels may reflect the human immunity function and can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of cancer.